IOP and Ocular Biometrics Changes After Phacoemulsification in Glaucoma Patients and Controls

Mai Nasser Abd Elmohsen

Status: Completed

Conditions: Cataract; Glaucoma

Treatments: Diagnostic Test: Ultrasound Biomicrosopy (UBM); Procedure: phacoemulsification and Intraocular lens implantation

Study type: Interventional

Funder types: Other

Identifiers

NCT04334473

N-45-2019

Details and patient eligibility

About

Effect of phacoemulsification on intraocular pressure has been studied with variable results.Furthermore, effect of phacoemulsification on ocular biometrics including anterior chamber depth and angle opening distance has also been studied. In our study we aim at establishing a quantitative relationship between preoperative ocular biometrics and postoperative intraocular pressure change and comparing this relationship in glaucomatous and non-glaucomatous eyes.

Full description

All patients will have the anterior chamber angle assessed by indentation gonioscopy preoperatively. Anterior Chamber Depth & lens thickness will be measured by Optical Biometry (lenstar 900) as well as measurement of the angle & lens vault using the Ultrasound Biomicrosopy (UBM) before and 1 month after cataract surgery. IOP will be measured pre- & postoperatively on day 7 and 30. Possible Risk (s): Risks of surgery(hemorrhage, endophthalmitis), Risks for investigations: minimal risk of infection To minimize the risk of infection: adherence to pre-& intraoperative infection-control measures, postoperative UBM is to be done at 1 month.

Enrollment: 37 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 40-70 years.
• Glaucomtous and nonglaucomatous participants with visually significant cataracts.
• Best-corrected visual acuity (BCVA) equal to or worse than 6/12.
• patients candidates for standard cataract surgeries without adjunctive procedure (e.g., pupil stretching or iris hooks).

Exclusion criteria

• Major intraoperative or postoperative complications from cataract surgery
• Peripheral anterior synechiae (PAS) detected by indentation gonioscopy.
• Uveitis, severe retinal diseases, or congenital Anomalies.
• History of ocular trauma or any intraocular Surgery. ocular trauma or any intraocular Surgery

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 1 patient group

cataract patients

Other group

Description:

Patients having cataract candidates for phacoemulsification with or without glaucoma are prepared to do cataract surgery with preoperative and postoperative assessment of intraocular pressure and ocular bio-metrics using UBM.

Treatment:

Procedure: phacoemulsification and Intraocular lens implantation

Diagnostic Test: Ultrasound Biomicrosopy (UBM)