IR, Inflammatory and Cardiovascular Markers in PCOS Among Obese and Non-obese Women

Taipei Medical University

Status: Unknown

Conditions: Polycystic Ovary Syndrome,; Insulin Resistance,

Study type: Observational

Funder types: Other

Identifiers

NCT01989039

Hsu2013-TMU-JIRB201307021

Details and patient eligibility

About

FPCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased insulin resistance and abnormal glucose metabolism. Low-grade chronic inflammation predicts cardiovascular outcomes and is observed in women with PCOS. However, obesity is also associated with increased inflammatory markers. Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and elevated inflammatory markers. To study the insulin resistance、inflammatory markers and cardiovascular risk in women with PCOS, body weight status should be considered. Investigator therefore conduct this retrospective study to evaluate the insulin resistance、inflammatory and cardiovascular markers between PCOS and non-PCOS among obese and non-obese women.

Enrollment: 800 estimated patients

Sex: Female

Ages: 13 to 48 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women had been fulfilled with whole anthropometric measurements, clinic and biochemical survey about insulin resistance, cardiovascular and inflammatory markers.

Exclusion criteria

• women who had been diagnosed with malignant tumor, Asherman's syndrome, Mullerian agenesis, ovarian failure, hyperprolactinemia, and chromosomal anomalies;
• women who had had menarche less than 1 years before evaluation or who were older than 49;
• women who received hormones or drugs for major medical diseases within three months.