Iris Color and Day-Night Changes in the Sympathovagal Ratio

Ankara Ataturk Sanatorium Training and Research Hospital

Status: Completed

Conditions: Iris Diseases

Treatments: Other: Iris Color Measurement , LF/HF Measurement

Study type: Observational

Funder types: Other

Identifiers

NCT05759715

1099/9.3.2016

Details and patient eligibility

About

Iris melanocytes are innervated by parasympathetic and sympathetic nerve endings. Light affects autonomic nervous system activity via the retino-hypothalamic pathway. The hypothesis that the day-to-night variations in the sympatovagal ratio (LF/HF) may differ among individuals with different brown iris patterns was tested.

Full description

A total of 621 healthy adults, aged between 16 and 50, with brown eyes and not diagnosed with a disease that might affect the autonomous nerve system were included in the study. A digital camera was used to acquire iris photos. Subjects were grouped into iris color groups (2-0 bg, 1-0 bg, 1-1 db, 1-1 lb, 2-0 b, and 1-0 b). Iris photos were analyzed with Picture Color Analyzer RBG software. The Central/Peripheral (R/RGB) ratio was used for objective distinction between the groups. Using 24-h Holter ECG monitoring, the change in the sympathovagal ratio from day (between 07:00 and 23:00 hrs) to night (between 23:00 and 07:00 hrs) was determined with the formula [(Day - Night) LF/HF)/Day LF/HF].

Enrollment: 621 patients

Sex: All

Ages: 16 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

A total of 650 healthy individuals between the ages of 16 and 50 .

Exclusion criteria

Diseases that could affect the autonomic nervous system; Obesity Obstructive sleep apnea syndrome Hypertension Diabetes mellitus Atrial fibrillation Coronary disease Heart failure Goiter, etc.

Trial design

621 participants in 6 patient groups

2-0 darkbown-green (2-0 bg)

Description:

Those with distinctively dark brown in the central area, slightly green in the peripheral area,

Treatment:

Other: Iris Color Measurement , LF/HF Measurement

1-0 lightbrown-green (1-0 bg).

Description:

Those with slightly dark brown in the central area and green in the peripheral area,

Treatment:

Other: Iris Color Measurement , LF/HF Measurement

dark brown (1-1 db)

Description:

Eyes with the same color structure in the central iris and the peripheral iris.

Treatment:

Other: Iris Color Measurement , LF/HF Measurement

light brown (1-1 lb)

Description:

Eyes with the same color structure in the central iris and the peripheral iris.

Treatment:

Other: Iris Color Measurement , LF/HF Measurement

dark brown (2-0 b)

Description:

Those with distinctively dark brown in the central iris area compared to the periphery .

Treatment:

Other: Iris Color Measurement , LF/HF Measurement

slightly dark brown (1-0 b)

Description:

Those with slightly dark brown (1-0 b) in the central iris area compared to the periphery .

Treatment:

Other: Iris Color Measurement , LF/HF Measurement