Iris Tissue in Primary Congenital Glaucoma

Assiut University

Status: Unknown

Conditions: Primary Congenital Glaucoma

Treatments: Procedure: Combined trabeculotomy-trabeculectomy with mitomycin c

Study type: Interventional

Funder types: Other

Identifiers

NCT04079725

primary congenital glaucoma

Details and patient eligibility

About

To present the histopathological features of the iris tissue in primary congenital glaucoma which may play a role in pathogenesis

Full description

Primary congenital glaucoma etiology still remains obscure . originally barkan , and later Worst , proposed that a membrane covered the anterior chamber angle and blocked aqueous outflow , but the presence of that membrane has not been established histopathologically to date . Now most authors believe that the site of obstruction is the trabecular meshwork rather than an overlying membrane . Maldevelopment of the anterior segment is present in all forms of congenital glaucoma . this maldevelopment may involve the trabecular meshwork alone or the trabecular meshwork in combination with the iris or cornea or both. In approcimately 50% of patients , isolated trabeculodysgensis is the only developmental ocular anomaly found .This is the classic defect found in primary congenital glaucoma .These eyes have no developmental anomalies of iris or cornea present except abnormal insertion of the iris into the angle

Enrollment: 15 estimated patients

Sex: All

Ages: 7 days to 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Typical symptoms of epiphora , photophobia and blepharospasm
2. corneal diameter > 13 mm
3. Increased ocular tension > 25 mmHg UGA using schiotz tonometer

Exclusion criteria

1. Infants with history of previous surgery
2. Secondary glaucoma
3. Glaucoma associated with other congenital anomalies

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Experimental : Infants with primary congenital glaucoma

Experimental group

Treatment:

Procedure: Combined trabeculotomy-trabeculectomy with mitomycin c