Iron Deficiency and TTG Normalization

Clalit Health Services

Status: Completed

Conditions: Celiac Disease in Children

Treatments: Other: Gluten free diet

Study type: Observational

Funder types: Other

Identifiers

NCT05675280

MMC-20-0021

Details and patient eligibility

About

The investigators conducted a retrospective, observational cohort study which enrolled CD subjects aged 2-18y, diagnosed between Jan 2016 and Dec 2020. Demographic and laboratory data were collected at diagnosis and 1y after adherence to GFD. ID was determined according to hemoglobin and ferritin levels. The investigators compared CD subjects with and without ID at CD diagnosis in relation to TTG normalization at 1y.

Enrollment: 118 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children (male and female) diagnosed with CD
• Age 2-18y

Exclusion criteria

• Total IgA deficiency
• Anemia due to other causes - anyone with anemia and normal or elevated ferritin levels (e.g. thalassemia, spherocytosis)
• Other chronic conditions increasing the risk of anemia or falsely elevated ferritin (e.g. inflammatory bowel disease, chronic kidney disease, infection)

Trial design

118 participants in 2 patient groups

Iron deficiency at diagnosis

Treatment:

Other: Gluten free diet

No iron deficiency at diagnosis

Treatment:

Other: Gluten free diet