IRON DEFICIENCY ANEMIA IN RELATION TO PINCH STRENGTH AND HAND DEXTERITY IN PRESCHOOL CHILDREN (IDA)

Cairo University (CU)

Status

Completed

Conditions

Iron Deficiency Anemia

Treatments

Diagnostic Test: CBC serum iron serum ferritin

Study type

Observational

Funder types

Other

Identifiers

NCT05959122

No: P.T.REC/012/001850

Details and patient eligibility

About

Anemia is a major public health problem among preschool-aged children. The evidence demonstrated that early childhood anemia is a strong predictor of adulthood anemia (Gessner, 2009). According to Egypt's Demographic and Health Survey (EDHS), prevalence rates of anemia in children aged 6-59 months ranged from 23% to 45% (EDHS, 2014). It is assumed that 50% of the cases of anemia are due to ID (Aref and Khalifa, 2019). The major health problem in Egypt is ID that affects 41.2% of children aged <5years (El-Asheer et al., 2021). The total prevalence of IDA in the Nile Delta region was 17.19% of the children (El-Shanshory et al., 2021). Iron is a trace element that is essential to form hemoglobin in red blood cells and to carry oxygen to peripheral tissues. In addition, iron plays essential functions in the mitochondria, which are crucial for regulating energy metabolism in the skeletal muscle (Kang and Li, 2012). And low iron levels limit oxygen bioavailability in the peripheral tissues, including skeletal muscle (Jolly et al., 2001).Yu-mi et al., (2020) found a low handgrip strength in anemic patients. Also, ID can impaired brain energy metabolism, along with hypo-myelination and impaired dopamine signaling, is consistently described as one of the mechanistic causes of the neurodevelopmental deficits associated with early-life ID (Thomas et al., 2020).

HYPOTHESES:

There is a relation between IDA and pinch strength and hand dexterity in preschool children.

RESEARCH QUESTION:

Is there a relation between IDA and pinch strength and hand dexterity in preschool children?

The purpose of the current study is to find the relation between IDA and:

Pinch grip strength (tripod and tip to tip grip strength).
Hand dexterity in preschool children.

Full description

i. Instrumentations for selection:

Fully automated blood cell counter. A complete blood count (CBC) is one of the most commonly and routinely done laboratory tests It will be obtained through the use of fully automated blood cell counter (sysmex-Xs 800i).
Beckman coulter-AU 480- blood chemistry auto-analyzer. It is the ideal primary chemistry analyzer for measurement of the amount of serum iron in the blood. ii. Instrumentations for assessment:

Updated 23/11/12

Baseline mechanical Pinch gauge (0-60 lb.) used to measure tripod pinch strength of dominance and non-dominance hands for all participated children.
Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2) The Bruininks-Oseretsky Test of Motor Proficiency is a standardized, norm-referenced measure

Inclusion Criteria:

Their age will be ranged from 5-6 years
The fifty anemic children will have microcytic hypochromic anemia: their Hb < 11.5 g/L (Hb from 11.0-11.4 is mild anemia and in moderate anemia Hb is from 8.0-10.9 (WHO, 2011). The serum iron is below 60 mcg/dL (Elngar et al., 2021). The Ferritin level

<12 µg/L for children in absence of infection (WHO, 2017). ( Appendix I).
They will be right handed.
They had no history of previous hand injuries, surgeries or other functional hand limitation.
All children will able to follow instructions and understand commands given during test procedures.
Their body mass index (BMI) will be ranged from 15.2 to 15.5 kg/m2 (WHO, 2007). (Appendix II).

B. Exclusion Criteria:

Children will exclude if they have:

Congenital or acquired deformity in the joints of upper limb.
Unhealed fracture in upper limb bones.
Systematic disease that cause anemia such as renal or hepatic failure or a history of bone disease.
Blood transfusion within 3 months before measuring the hematological indices.
Documented trauma in the previous 12 months in the muscle fibers, or those taking medication that affecting strength.
Children begin with musculoskeletal problems or neurological disorders that affected their upper extremities

Enrollment

100 patients

Sex

All

Ages

5 to 6 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Their age will be ranged from 5-6 years
The fifty anemic children will have microcytic hypochromic anemia: their Hb < 11.5 g/L (Hb from 11.0-11.4 is mild anemia and in moderate anemia Hb is from 8.0-10.9 (WHO, 2011). The serum iron is below 60 mcg/dL (Elngar et al., 2021). The Ferritin level

<12 µg/L for children in absence of infection (WHO, 2017). ( Appendix I).
They will be right handed.
They had no history of previous hand injuries, surgeries or other functional hand limitation.
All children will able to follow instructions and understand commands given during test procedures.
Their body mass index (BMI) will be ranged from 15.2 to 15.5 kg/m2 (WHO, 2007). (Appendix II).

Exclusion Criteria:

Children will exclude if they have:
1. Congenital or acquired deformity in the joints of upper limb.
2. Unhealed fracture in upper limb bones.
3. Systematic disease that cause anemia such as renal or hepatic failure or a history of bone disease.
4. Blood transfusion within 3 months before measuring the hematological indices.
5. Documented trauma in the previous 12 months in the muscle fibers, or those taking medication that affecting strength.
6. Children begin with musculoskeletal problems or neurological disorders that affected their upper extremities
7. Children who practice in any regular sport activities involving the upper extremities.8)