Iron Deposits in the Pancreas by MRI Method of Dialysis Patients With Hemosiderosis Iatrogenic (ERDFP)

Ramsay Générale de Santé

Status: Not yet enrolling

Conditions: Dialysis; Iatrogenic Hemosiderosis; Iron Deposition

Treatments: Procedure: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT05593068

ERDFP

Details and patient eligibility

About

Recently, a multidisciplinary scientific conference proposed to consider iron overload in dialysis patients as pathological only in the event of demonstration of radiological (in MRI), pancreatic or cardiac ferric deposits.

In this context, the aim of the proposed scientific study is to demonstrate the presence of ferric deposits in the pancreas by T2* MRI in dialysis patients with radiological hepatic iron overload, particularly in cases of moderate and severe iron overload.

Enrollment: 185 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male, female, over 18 years old
• Patient on hemodialysis or peritoneal dialysis at the Claude Galien Private Hospital
• Patient on dialysis who has undergone one (or more) abdominal MRI for iron quantification
• Patient who has signed a non-objection form for the retrospective use of their MRI, medical and biological data for the purpose of scientific study

Exclusion criteria

• Patient who has signed a form to object to the use of their health data
• Pregnant woman
• Poor adherence to the dialytic technique
• Severe cognitive impairment
• Hepatic cirrhosis
• Frank inflammatory syndrome or an active infectious disease
• Genetic hemochromatosis and transfusion hemosiderosis of hemoglobinopathies and hematological diseases
• Recent major bleeding (< 3 months)
• Recent major surgery (< 3 months)
• Transfusion dependence
• Progressive malignant disease
• Pacemakers incompatible with an MRI and metal heart valves

Trial design

185 participants in 1 patient group

Dialysed patients with suspicion of hepatic iron

Description:

Patients on dialysis at Claude Galien Private Hospital who had one or more MRI scans to monitor possible hepatic iron overload between May 2012 and March 2018.

Treatment:

Procedure: MRI