Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

H

HaEmek Medical Center, Israel

Status

Completed

Conditions

Thalassemia
Sickle Cell Disease

Treatments

Other: Medical Chart Summary

Study type

Observational

Funder types

Other

Identifiers

NCT00972231
0133-08-EMC

Details and patient eligibility

About

Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients. Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied. The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.

Full description

Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center. Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Enrollment

93 patients

Sex

All

Ages

5 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients in follow up with available medical charts.

Exclusion criteria

Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.

Trial design

93 participants in 2 patient groups

Thalassemia Group
Description:
Patients suffering from Thalassemia Major and patients with Thalassemia Intermedia
Treatment:
Other: Medical Chart Summary
Sickle Cell Group
Description:
Patients with Sickle Cell Anemia and Sickle Cell Thalassemia
Treatment:
Other: Medical Chart Summary

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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