Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia

HaEmek Medical Center, Israel

Status: Completed

Conditions: MRI; Iron Overload; Sickle Cell Thalassemia; Sickle Cell Anemia

Treatments: Other: Cardiac and Liver T2* MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT00512226

0037-07-EMC

Details and patient eligibility

About

Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't develope significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpouse of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and cardiac T2*MRI in order to determine the cardiac and liver iron.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All the patients with Sickle cell anemia and Sickle cell Thalasemia that are currently in follow up at the Pediatric Hematology Unit

Exclusion criteria

• Age below 18 years.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)