Irreversible Electroporation Ablation for Colorectal Metastases to the Lung

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Colorectal Metastases to the Lung

Treatments: Device: Irreversible Electroporation Ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT02461550

15-001

Details and patient eligibility

About

The investigators are investigating the use of a new cancer treatment called Irreversible Electroporation (IRE). This treatment delivers electrical energy between two needles placed in a cancer. The electrical energy causes cells to die. While this has been used in patients for different applications, the investigators are trying to understand how safe and well it works in colon cancer that has spread to the lung. Once the irreversible electroporation procedure is completed during the operation, the surgeon will then remove the cancer according to standard procedure. As part of the study, they will be measuring safety of the electrical energy delivered and will be reviewing the resected specimen under the microscope.

Enrollment: 2 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed Colorectal cancer with oligometastatic colorectal cancer in the lung
• Lung lesion size is greater than 1 cm
• Patient will undergo surgical resection as per consultation with their thoracic surgeon and medical oncologist
• Patient is cleared to undergo paralytic anesthesia.
• Patients 18 years old and older

Exclusion criteria

• Patients with history of cardiac dysrhythmia
• Known heart failure (EF < 40%)
• Pacemaker/defibrillator
• Patient's with any metallic cardiac implant
• Patient on anti-coagulation therapy and are unable to stop therapy for the perioperative period
• Women who are pregnant and/or nursing

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

IRE procedure

Experimental group

Description:

The IRE procedure will be performed in the operating room at the time of scheduled clinical resection of colorectal lung metastases by the surgeon with guidance from the Interventional Radiologist.

Treatment:

Device: Irreversible Electroporation Ablation