Irreversible Electroporation (NanoKnife) for the Treatment of Pancreatic Adenocarcinoma

Poitiers University Hospital

Status

Completed

Conditions

Pancreatic Adenocarcinoma

Interventional Imaging

Treatments

Device: NanoKnife

Study type

Interventional

Funder types

Other

Identifiers

NCT03105921

IRECAP

Details and patient eligibility

About

The aim of the study is to evaluate the use of irreversible electroporation in the treatment of locally advanced cancers of the head of pancreas with vascular spread. This technique would allow to treat the unresectable part of the tumor to make it more accessible for a secondary surgery.

Enrollment

20 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with histologically proven adenocarcinoma of the head of the pancreas (fine needle aspiration or biopsy)
Pancreatic adenocarcinoma locally advanced on imaging at diagnosis
Tumor of less than 7 cm in largest diameter
No chemotherapy or abdominal radiotherapy within five years before the inclusion in the study

Exclusion criteria

Pancreatic adenocarcinoma of more than 7 cm of diameter or immediately operable on imaging data
Patient with contraindication of NanoKnife use
Patient with neurostimulator
Epileptic patient or with a myocardial infarction lasting less than 2 months
Presence of visceral or lymph node metastases or peritoneal carcinosis at the initial workup
Patient who cannot be treated with muscle blockers (curare)
Patient with a metallic stent or a medical device implanted near the area treated by electroporation