Irrigating Fluid and Blood Coagulation

Seoul National University

Status: Completed

Conditions: Blood Coagulation Disorder

Treatments: Other: A mixture of 2.7% sorbitol-0.54% mannitol solution

Study type: Observational

Funder types: Other

Identifiers

NCT03105180

B-1703/386-303

Details and patient eligibility

About

Irrigating fluid absorbed during the endoscopic surgery may alter whole blood coagulation. However, little is known about the dose-response relationships of hemodilution. The investigators have therefore performed the present study to measure the effect of a mixture of 2.7% sorbitol-0.54% mannitol solution on the coagulation pathway according to the hemodilution level using a rotational thromboelastometry (ROTEM®) tests.

Enrollment: 12 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• age: 20 to 65 years
• Body weight > 50 kg
• Volunteers who provided informed consent

Exclusion criteria

• Hematologic disease
• Anticoagulant medication

Trial design

12 participants in 4 patient groups

0% dilution

Description:

Blood specimen which was diluted with 0% level using a mixture of 2.7% sorbitol-0.54% mannitol solution

10% dilution

Description:

Blood specimen which was diluted with 10% level using a mixture of 2.7% sorbitol-0.54% mannitol solution

Treatment:

Other: A mixture of 2.7% sorbitol-0.54% mannitol solution

20% dilution

Description:

Blood specimen which was diluted with 20% level using a mixture of 2.7% sorbitol-0.54% mannitol solution

Treatment:

Other: A mixture of 2.7% sorbitol-0.54% mannitol solution

40% dilution

Description:

Blood specimen which was diluted with 40% level using a mixture of 2.7% sorbitol-0.54% mannitol solution

Treatment:

Other: A mixture of 2.7% sorbitol-0.54% mannitol solution