Is Caffeine an Environmental Modifier in Huntington's Disease? (CrEAM-HD)

University Hospital, Lille

Status: Completed

Conditions: Huntington Disease

Study type: Observational

Funder types: Other

Identifiers

NCT03034122

2016-A00892-49 (Other Identifier)

2015_67

Details and patient eligibility

About

The aim of the study is to establish if caffeine consumption is associated with the evolution of the disease in premanifest HD.

Enrollment: 77 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HD mutation carriers (>36 CAG)
• premanifest (total motor UHDRS < 5)
• estimated time to diagnosis between 3 and 10 years
• adults older than 21 years (in order to exclude juvenile patients who begin the disease before 21 years)
• informed consent signed
• with a social protection

Exclusion criteria

• MRI contraindication
• pregnant and lactating women
• People under guardianship, trusteeship, deprive of freedom