Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism? (HEMEP)

Centre Hospitalier Universitaire, Amiens

Status: Enrolling

Conditions: Hematopoiesis; Pulmonary Embolism

Treatments: Biological: blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT04711746

PI2020_843_0117

Details and patient eligibility

About

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Enrollment: 544 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
• For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.

Exclusion criteria

• Age superior to 65 years old,
• Active cancer

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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544 participants in 2 patient groups

Previous proximal unprovoked pulmonary embolism

Experimental group

Treatment:

Biological: blood sample

Previous proximal provoked pulmonary embolism

Active Comparator group

Treatment:

Biological: blood sample