Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

ART Fertility Clinics LLC

Status: Enrolling

Conditions: IVF; Miscarriage; Miscarriage, Recurrent; Infertility, Female

Treatments: Diagnostic Test: Transvaginal ultrasound; Diagnostic Test: Blood test AMH

Study type: Observational

Funder types: Other

Identifiers

NCT05969574

2305-ABU-007-LM

Details and patient eligibility

About

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

Full description

By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function.

Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

Enrollment: 2,059 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai)

Exclusion criteria

1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT))
2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation
3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound
4. History of ovarian surgery, chemotherapy, or radiation therapy
5. Known genetic disorder or chromosomal abnormality
6. BMI >40Kg/m2
7. Currently using hormonal contraception or hormone replacement therapy

Trial design

2,059 participants in 4 patient groups

AMH <1.3, at least 1 pregnancy or at least 1 miscarriage

Description:

Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

Treatment:

Diagnostic Test: Blood test AMH

Diagnostic Test: Transvaginal ultrasound

AMH <1.3, at least 1 pregnancy and no miscarriage

Description:

Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

Treatment:

Diagnostic Test: Blood test AMH

Diagnostic Test: Transvaginal ultrasound

AMH ≥ 1.3, at least 1 pregnancy or at least 1 miscarriage

Description:

Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.ons.

Treatment:

Diagnostic Test: Blood test AMH

Diagnostic Test: Transvaginal ultrasound

AMH ≥1.3, at least 1 pregnancy and no miscarriage

Description:

Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.

Treatment:

Diagnostic Test: Blood test AMH

Diagnostic Test: Transvaginal ultrasound