Is Eovist Suitable for Arterial-Phase MR Imaging of Liver

University of Michigan

Status: Completed

Conditions: Liver Disease

Treatments: Procedure: Non Eovist Contrast; Procedure: Eovist Contrast

Study type: Interventional

Funder types: Other

Identifiers

NCT02684526

HUM00038856

Details and patient eligibility

About

To examine the quality of liver images produced when the contrast agent Eovist is used during MRI.

Full description

Researchers will review data from the Eovist MRI and compare the scan with previous MRI exams the patient had with the same or other contrast agents.

To determine the efficacy of Eovist contrast agent in producing MRI images of the liver. We will monitor patients for any unusual symptoms (adverse events) when the contrast is given.

Patients are asked to hold their breath during an MRI scan. Eovist may interfere with the "breath hold" which could result in more breathing artifacts (based on a qualitative scale) on arterial images when the patients are given Eovist vs. other contrast agents.

Enrollment: 198 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. You have had a scheduled MRI(magnetic resonance imaging) scan using the contrast agent EOVIST.
2. Male and females 21 years of age or older.

Exclusion criteria

1. Does not have a contraindication for MRI (e.g. cardiac pacemaker, ferromagnetic or metallic implants).
2. Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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198 participants in 2 patient groups

Eovist Contrast agent

Active Comparator group

Description:

To determine if Eovist contrast agent induces a transient abnormal sensation at first pass, which prevents patients from holding their breath at end of arterial phase liver MRI scans.

Treatment:

Procedure: Eovist Contrast

Non Eovist Contrast agents

Active Comparator group

Description:

To determine if using non-Eovist contrast agents produce the same abnormal sensation at first pass, which prevents patients from holding their breath at end of arterial phase liver MRI scans. Determine if this event is exclusive to Eovist contrast.

Treatment:

Procedure: Non Eovist Contrast