Is Hemodialysis Associated With Cardiac Markers Change?

Ziv Hospital

Status: Completed

Conditions: Renal Insufficiency, Chronic

Treatments: Procedure: Hypothermic dialysis followed with routine dialysis; Procedure: Routine dialysis followed with hypothermic dialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT04929366

0101-17-ZIV

Details and patient eligibility

About

Hemodialysis (HD) triggers recurrent and cumulative ischemic insults to the brain and the heart. Cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis. The aim of the study was to compare HD with cooled dialysate with routine dialysis in terms of hemodynamic stability and levels of high sensitivity Troponin I (hs-TnI) and N-terminal pro b-type natriuretic peptide (NTproBNP) post dialysis

Enrollment: 45 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with renal insufficiency treated with dialysis for a period of at least three months.

Exclusion criteria

• Patients who experienced myocardial infarction during the three months prior to the start of the study
• Patients who underwent vascular surgery during the last month
• Patients who experienced chest pain at rest during the last week before the start of the trial - Patients who had to discontinue dialysis prematurely due to hemodynamic instability.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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45 participants in 2 patient groups

End-stage kidney patients treated in the dialysis unit group 1

Experimental group

Treatment:

Procedure: Hypothermic dialysis followed with routine dialysis

End-stage kidney patients treated in the dialysis unit group 2

Experimental group

Treatment:

Procedure: Routine dialysis followed with hypothermic dialysis