Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy

Yuzuncu Yıl University

Status and phase: Completed; Phase 4

Conditions: Oral Mucositis

Treatments: Drug: Sodium bicarbonate; Drug: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT05818007

YYU-06/03.07.2019

Details and patient eligibility

About

Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT.

Enrollment: 40 patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children who receive chemotherapy
• hospitalized patient

Exclusion criteria

• Allergy about using drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups

hyaluronic acid

Experimental group

Description:

The hyaluronic acid is a natural polysaccharide composed of D-glucuronic acid and N-acetyl-D-glucosamine and is synthesized as a linear polymer. The majority of the cells have a capacity to synthesize HA at a varying extent in the cell cycle.

Treatment:

Drug: Hyaluronic acid

sodium bicarbonate

Active Comparator group

Treatment:

Drug: Sodium bicarbonate