Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Status: Completed

Conditions: Proton Pump Inhibitor Adverse Reaction

Treatments: Diagnostic Test: Blood for zonulin level was drawn from the group.

Study type: Interventional

Funder types: Other

Identifiers

NCT06268834

ZonulinPPI

Details and patient eligibility

About

Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.

Full description

The study included a total of 75 participants, with 45 individuals classified as long-term PPI users and 30 as non-PPI users. The PPI user group was defined as those who had been consistently using PPIs (specifically omeprazole, lansoprazole, pantoprazole, esomeprazole, or rabeprazole) on a daily basis for a minimum of 6 months or at least twice a week for a minimum of 2 years. The control group comprised individuals who had never used PPIs. Venous blood samples were taken from all participants to measure serum zonulin levels.

Enrollment: 75 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

The patient group was patients taking long-term PPIs (omeprazole, lansoprazole, pantoprazole, esomeprazole and rabeprazole) every day for at least 6 months or at least twice a week for at least 2 years.

A control group was formed from individuals who had never used PPI.

Exclusion criteria

Those with inflammatory bowel disease, celiac disease, type 1 diabetes, active gastroenteritis, acute kidney failure, chronic kidney failure, and those who had used antibiotics for any reason in the last 3 months, as well as those receiving probiotic drug support, were not included in the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 2 patient groups

Using PPI

Experimental group

Description:

Group receiving a long-term PPI (omeprazole, lansoprazole, pantoprazole, esomeprazole and rabeprazole) every day for at least 6 months or at least twice a week for at least 2 years.

Treatment:

Diagnostic Test: Blood for zonulin level was drawn from the group.

Control

Experimental group

Description:

A control group was formed from individuals who had never used PPI.

Treatment:

Diagnostic Test: Blood for zonulin level was drawn from the group.