Is Lymphocyte Subtype Important for Acute Pancreatitis Severity?

Istanbul Training and Research Hospital

Status: Completed

Conditions: Lymphocytic Infiltrate; Immune System Diseases; Pancreatitis

Treatments: Diagnostic Test: Flow Cytometric analysis

Study type: Observational

Funder types: Other

Identifiers

NCT04502940

Pancreatitis 01.06.2020

Details and patient eligibility

About

Pancreatitis is a common complication especially in patients with gallbladder stones, most patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20% of patients, the disease is severe and mortality rates of up to 30% are detected in these patients. In the evaluation of acute biliary pancreatitis, many scoring systems have been established (Atlanta, Ranson, APACHE, BISAP etc.) from past to present to determine morbidity and mortality of the disease.

In this study, the investigators aimed to evaluate the correlation between morbidity and mortality of acute biliary pancreatitis and lymphocyte subtypes with Flow-cytometry.

Full description

Pancreatitis is a common complication especially in patients with gallbladder stones, most patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20% of patients, the disease is severe and mortality rates of up to 30% are detected in these patients. In patients with severe pancreatitis, aggressive fluid replacement, organ damage follow-up, appropriate antibiotherapy, and endoscopic sphincterotomy and radiological interventions may be of great benefit. In the evaluation of acute biliary pancreatitis, many scoring systems have been established (Atlanta, Ranson, APACHE, BISAP etc.) from past to present to determine morbidity and mortality of the disease. There are limited number of studies in the literature about the immune parameters in the evaluation of acute pancreatitis. In a studies, serum inflammatory markers such as IL-1, IL-6 and CD4, CD8 T lymphocyte and Treg population were evaluated.Treg cells are reported to be an independent prognostic factor in determining the severity of acute pancreatitis. In patients diagnosed with acute biliary pancreatitis, determination of the course of the disease at the time of diagnosis is extremely important for treatment and survival.

In this study, the investigators aimed to evaluate the correlation between morbidity and mortality of acute biliary pancreatitis with lymphocyte subtypes via Flow-cytometry.

Enrollment: 53 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-80 years old
• Diagnosis of acute biliary pancreatitis
• Sign the voluntary consent form

Exclusion criteria

• Being under 18 or older than 80
• Not signing the voluntary consent form
• Pancreatitis resulting from an interventional procedure (ERCP, surgery, etc.)
• Pregnant women
• Being a history of immunodeficiency
• Cancer history

Trial design

53 participants in 4 patient groups

Mild pancreatitis

Description:

Patients with mild acute biliary pancreatitis according to Atlanta classification

Treatment:

Diagnostic Test: Flow Cytometric analysis

Moderate Pancreatitis

Description:

Patients with moderate acute biliary pancreatitis according to Atlanta classification

Treatment:

Diagnostic Test: Flow Cytometric analysis

Severe pancreatitis

Description:

Patients with severe acute biliary pancreatitis according to Atlanta classification

Treatment:

Diagnostic Test: Flow Cytometric analysis

Control

Description:

Healthy volunteers

Treatment:

Diagnostic Test: Flow Cytometric analysis