Is Oxidative Stress in Semen Reduced by Lifestyle Intervention

Peter Humaidan

Status: Completed

Conditions: Oligospermia

Treatments: Dietary Supplement: Omega 3

Study type: Interventional

Funder types: Other

Identifiers

NCT03898752

MiOxysis_Skive

Details and patient eligibility

About

In this study we aim to investigate whether a 3-month life-style intervention would reduce oxidative stress (OS) in semen in men of infertile couples attending IVF-treatment. Men with a DFI above 15% (SCSA method) are recruited for intervention with a 3-month follow-up.

It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.

Enrollment: 31 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• DFI>15
• Attending IVF treatment for unknown or male factor infertility.

Exclusion criteria

• Genetic diseases
• Azospermia

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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31 participants in 1 patient group

Lifestyle intervention

Experimental group

Description:

Diet, omega-3 fish oil (1g daily), CoQ10 (100 mg/day) and a normal Multi-vitamin, Smoking cessation, weight loss, exercise,

Treatment:

Dietary Supplement: Omega 3