Is Routine Use of Histopathological Examination Necessary After Cholecystectomy ?

Sisli Hamidiye Etfal Training and Research Hospital

Status: Completed

Conditions: Cholelithiasis

Study type: Observational

Funder types: Other

Identifiers

NCT02654873

Sislietfal

Details and patient eligibility

About

Cholecystectomy has been made with benign conditions usually. The aim of this study is to compare the macroscopic evaluations of the cholecystectomy specimens with it's histopathological examinations.

Full description

Cholecystectomy is one of the most frequently performed surgery in the world and often made with benign conditions. Routinely cholecystectomy specimens sent for histopathologic examination. The histopathologic examination of the cholecystectomy specimens are benign in most of the cases and the incidental malignancy of the gallbladder is 2-2.9% in the literature. The histopathologic evaluations of the gallbladder come with additional workload for pathology and surgery departments. Also there is additional cost for the patients. Because of that the idea of selective histopathologic examination has been raised.

Enrollment: 1,000 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject has cholelithiasis

Exclusion criteria

• Subject has acute cholecystitis
• Subject has perforated gallbladder
• Subject has malignancy
• Subject has polyps in the gallbladder
• Subject has increasing wall thickness of the gallbladder
• Subject has malignancy in the preoperative ultrasonography in the gallbladder
• Subject has pregnancy

Trial design

1,000 participants in 3 patient groups

Benign

Description:

Benign pathology specimens with macroscopically

Suspicious

Description:

Suspicious group includes the conditions such as increasing of the gallbladder wall thickness, having calcifications or polyps in the gallbladder.

Malign

Description:

Malign group includes the conditions such as detecting mass or irregularities in the gallbladder wall.