Is Serum YKL-40 Capable of Predicting Intrauterine Growth Restriction (IUGR) and Preeclampsia?

Zealand University Hospital

Status: Unknown

Conditions: Preeclampsia; Intrauterine Growth Restriction

Treatments: Procedure: ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT00836524

SJ-55

Details and patient eligibility

About

Objective: To investigate the role of maternal serum YKL-40 and uterine artery doppler, at gestational age 12, 20, 25 and 32 weeks, and the relation to preeclampsia and intrauterine growth restriction. The serum marker YKL-40 is related to conditions involving inflammation, infection, tissue remodeling, fibrosis and cancer. IUGR and preeclampsia are known to be related to inflammation and tissue remodeling.

Methods: women attending screening for downs syndrome is scanned with uterine artery doppler and delivered blood samples at GA 12, 20, 25 and 32 respectively. When pregnancy outcome is registered by medical records blood samples are retrieved and analyzed for serum YKL-40. Serum YKL-40 are correlated to the presence of bilateral notching, preeclampsia and different degrees of intrauterine growth restriction.

Enrollment: 2,000 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant danish speeking women

Exclusion criteria

• Conditions/diseases involving chronical inflammation, or immunological activity

Trial design

2,000 participants in 1 patient group

1

Description:

Pregnant women are included when they attend nuchal transcluency examination and will during their pregnancy be examined 4 times with ultrasound

Treatment:

Procedure: ultrasound