Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?

University Hospital Basel

Status: Completed

Conditions: Periprosthetic Joint Infection (PJI)

Treatments: Other: data collection to classify infection status

Study type: Observational

Funder types: Other

Identifiers

NCT05117671

2021-00133 mu21Clauss;

Details and patient eligibility

About

This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).

Full description

Periprosthetic joint infection (PJI) is a major burden for healthcare systems. The European Bone and Joint Infection Society (EBJIS) proposed a new set of criteria introducing a three level 'traffic light' distinction: Infection Unlikely, Infection Confirmed but also an intermediate group called Infection Likely (but nor confirmed). This retrospective multi-center, multi-national cohort study is to validate the EBJIS Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).

Enrollment: 1,554 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• THA/TKA patients that underwent revision surgery regardless of final aseptic vs. infected diagnosis between 01.01.2013 until 31.12.2018

Exclusion criteria

• less than two years follow up
• less than four intraoperative microbiology samples (synovial fluid, tissue samples, implant sonication)
• no preoperative/intraoperative synovial fluid differential leukocyte count

Trial design

1,554 participants in 1 patient group

revision total hip or knee arthroplasties

Description:

THA/TKA patients that underwent revision surgery between 01.01.2013 until 31.12.2018

Treatment:

Other: data collection to classify infection status