Is the Efficacy of Epidural Steroid Injections Related to the Different Volume Injections?

Neslihan Uztüre

Status: Completed

Conditions: Pain

Treatments: Drug: Epidural Volume; Drug: Bupivacaine; Drug: Triamcinolone

Study type: Interventional

Funder types: Other

Identifiers

NCT02343432

03-2008/23

Details and patient eligibility

About

This study was aimed to investigate the impact of using different epidural volumes.

Patients with acute discogenic pain were included in the study.

Full description

Objectives: This study was aimed to investigate the impact of using different epidural volumes.

Methods: Seventy five patients with acute discogenic pain were included in the study.The patients were randomly assigned to three groups. All patients received a single epidural dose of triamcinolone [80 mg] and 12.5 mg bupivacaine combination. The patients in Group 1, Group 2 and Group 3 received a volume of 10 mL, 15 mL, and 20 mL by epidural injections, respectively. The efficacy of treatment was assessed with VAS (visual analog scale) [O= no pain, 10 = unbearable pain], SLET(straight leg elevation test) [0° = worst, 85° = best], and Oswestry Disability Index; ODI [0% to 20%:minimal disability , 80% to 100%:bed bound patients] before and 2 weeks after the EPSI.

Enrollment: 75 patients

Sex: All

Ages: 25 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• acute discogenic pain with less than three months duration not responding to other modalities of conservative management [NSAIDs, physiotherapy, bracing, etc.],
• radiological disc bulging accompanying unilateral root impingement symptoms,
• an Oswestry daily activity score more than 20 percent, and
• resistance to treatment.

Exclusion criteria

• Patients with bilateral root impingement symptoms, neurological deficits, and/or history of previous lumbar disc surgery, severe cardiac, pulmonary, gastrointestinal, renal diseases, glaucoma, urinary retention, and/or known allergy to the drugs used in the study were excluded from the study.

Trial design

75 participants in 3 patient groups

Epidural Volume 10mL

Experimental group

Description:

Epidural Volume 10mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 10mL Intervention: Drug: Bupivacaine 12.5mg

Treatment:

Drug: Epidural Volume

Drug: Triamcinolone

Drug: Bupivacaine

Epidural Volume 15mL

Experimental group

Description:

Epidural Volume 15mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 15 mL Intervention: Drug: Bupivacaine 12.5mg

Treatment:

Drug: Epidural Volume

Drug: Triamcinolone

Drug: Bupivacaine

Epidural Volume 20mL

Experimental group

Description:

Epidural Volume 20mL, Intervention: Drug: Triamcinolone 80 mg Intervention: Drug: Epidural Volume 20 mL Intervention: Drug: Bupivacaine 12.5mg

Treatment:

Drug: Epidural Volume

Drug: Triamcinolone

Drug: Bupivacaine