Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

Adiyaman University Research Hospital

Status: Completed

Conditions: Dizziness

Treatments: Other: LFTs

Study type: Observational

Funder types: Other

Identifiers

NCT02733549

ADYU-4

Details and patient eligibility

About

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

Full description

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.

Enrollment: 198 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study

Exclusion criteria

1. Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection
2. Patients with any central dizziness attacks
3. Patients with hemodynamically unstable and emesis;
4. Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen)
5. Patients who was experienced dizziness with systemic diseases
6. Patients with any neurological disorders
7. Patient who do not want to participate in the study

Trial design

198 participants in 2 patient groups

patient

Description:

Patients with sudden onset dizziness (SOD) analysed LFTs

Treatment:

Other: LFTs

control

Description:

The control group with 98 healthy volunteer analysed LFTs

Treatment:

Other: LFTs