Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia?

Rigshospitalet

Status

Completed

Conditions

Healthy Volunteers

Secondary Hyperalgesia

Pain

Magnetic Resonance Imaging

Treatments

Device: MRI-scan

Study type

Interventional

Funder types

Other

Identifiers

NCT02567318

SM3-MSH-2015

Details and patient eligibility

About

The purpose of this prospective study is to investigate the degree of association between the volume of important pain-relevant structures in the brain and the size of the areas of secondary hyperalgesia.

Full description

The healthy study participants will be included from the cohort of a previous study (NCT02527395) where areas of secondary hyperalgesia, heat pain detection thresholds, pain during 1 min. thermal stimulation and test results from the Pain Catastrophizing Scale and the Hospital Anxiety and Depression Score will be retrieved. The study consists of 1 study day. The study day will be conducted at a maximum of 2 months and a minimum of 2 weeks after the completion of the previous study (NCT02527395).The results of the previous study (NCT02527395) will be blinded until all participants have completed the study day.

All study participants will complete a MRI-scan of the brain.

The MRI scans will be performed with a Siemens MAGNETOM Verio 3 tesla, with b17 software, and a 32-channel head coil. The MRI-scan sequence is as follows:

3D Localiser
3D T1 weighted iso
AX Diffusion tensor imaging
AX Epi resting state fMRI
AX Gre field map
AX Epi ASL
AX T2-weighted blade
AX T2-weighted flair
AX T2-weighted* Gre

Total MRI-scan time is estimated to approximately 40 minutes.

Enrollment

120 estimated patients

Sex

Male

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age >18 years and <35 years
Speak and understand Danish
Male sex
Study participants who have understood and signed the informed consent
No prescription medicine during the last 30 days.
Have participated and completed the study with the identifier: NCT02527395.

Exclusion criteria

Study participants that cannot cooperate to the test.
Study participants who have a weekly intake of >21 units of alcohol, or a have consumed >3 units of alcohol within 24 hours before experimental day.
Study participants with a substance abuse, assessed by the investigator.
Study participants, who have consumed analgesics less than 3 days before experimental day.
Study participants, who have consumed antihistamines less than 48 hours before experimental day.
Study participants, who have consumed antidepressant medication during the last 30 days before experimental day.
Study participants with chronic pain.
Study participants with neurological illnesses.
Study participants with psychiatric diagnoses.
Study participants with a Body Mass Index of >30 kg/m2 or <18 kg/m2
Study participants with Contraindications to MRI
Study participants that decline information regarding potential pathological findings in relation to the MRI.
Study participants that have any kind of trauma resulting in pain and administration of analgesics in the period between experimental pain testing and MRI-scan.
Study participant that experience a head trauma in the period between the experimental pain testing and the MRI-scan.