Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

Calla IVF Center

Status: Completed

Conditions: Blastocyst IVF; Pregnancy Rate IVF

Treatments: Other: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes

Study type: Observational

Funder types: Other

Identifiers

NCT06795984

CALLAIVF KIR HLAC

Details and patient eligibility

About

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Enrollment: 80 patients

Sex: Female

Ages: 21 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female patients aged 20-40 years.
• Normal uterine cavity confirmed by hysteroscopy or sonohysterography.
• At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL).

Exclusion criteria

• uterine abnormalities,
• systemic autoimmune diseases,
• severe male infertility factors.

Trial design

80 participants in 2 patient groups

KIR AA (Group A)

Description:

In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). A KIR AA haplotype is defined as cen-A and tel-A

Treatment:

Other: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes

KIR non AA (Group B)

Description:

In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). KIR Bb haplotype is described as cenB/telB, cenA/telB, or cenB/telA

Treatment:

Other: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes