ClinicalTrials.Veeva

Menu

İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels?

Z

Zekai Tahir Burak Women's Health Research and Education Hospital

Status

Unknown

Conditions

Mild Pre-eclampsia
Severe Preeclampsia

Study type

Observational

Funder types

Other

Identifiers

NCT01906567
zekai tahir burak heavy metal

Details and patient eligibility

About

The purpose of this study, to investigate whether severity of preeclampsia is associated with altered levels of heavy metals (Cd, Hg, arsenic and Pb) in maternal blood, fetal blood, and maternal hair.

Full description

The unfavorable effects of heavy metals on human health is well known. The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. They may be toxic at the levels previously thought to have no adverse effect on human.In utero environmental exposures can have long term consequences to health and development.İn spite of what is known about the neurotoxicity from exposure to heavy metals, the health effects from co-exposure to these chemicals and the biologically effective doses are not known exactly.

Preeclampsia is associated with increased maternal and infant mortality and morbidity. The exact etiology is not clear. Several evidences indicate that various environmental factors and elements may play a role in pre-eclampsia.

significant increase in Pb, cadmium (Cd), copper (Cu) and magnesium (Mg) and decrease in zinc (Zn) in amniotic fluid are associated with preeclampsia. Pb as this metal has well known adverse effects on renal system and blood pressures Effects of Pb on reproductive system have been studied intensively, e.g. other pregnancy outcome and pregnancy hypertension.

However, the relationship between the severity of pre-eclampsia and heavy metal levels have not been investigated.

The purpose of this study, to investigate whether severity of preeclampsia is associated with altered levels of heavy metals (Cd, Hg, arsenic and Pb) in maternal blood, fetal blood, and maternal hair.

Enrollment

90 estimated patients

Sex

Female

Ages

18 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of preeclampsia (diagnosed per ACOG criteria)

Exclusion criteria

known chronic disease multipl pregnancies

Trial design

90 participants in 3 patient groups

severe preeclamptic women
Description:
Severe preeclampsia is defined as the presence of 1 of the following symptoms or signs in the presence of preeclampsia: • SBP of 160 mm Hg or higher or DBP of 110 mm Hg or higher on 2 occasions at least 6 hours apart • Proteinuria of more than 5 g in a 24-hour collection or more than 3+ on 2 random urine samples collected at least 4 hours apart • Pulmonary edema or cyanosis • Oliguria (\< 400 mL in 24 h) • Persistent headaches • Epigastric pain and/or impaired liver function • Thrombocytopenia • Oligohydramnios, decreased fetal growth, or placental abruption
mild preeclamptic women
Description:
Mild preeclampsia is defined as the presence of hypertension (BP ≥140/90 mm Hg) on 2 occasions, at least 6 hours apart, but without evidence of end-organ damage in the patient.
Healthy Pregnant Women
Description:
healthy pregnant women at term who not developed any complication of pregnancy

Trial contacts and locations

2

Loading...

Central trial contact

sibel ozler; ayse kirbas

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems