Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients

Assiut University

Status: Not yet enrolling

Conditions: Hyperuricemia; NAFLD (Nonalcoholic Fatty Liver Disease); Liver Fibrosis

Treatments: Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .; Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan; Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Study type: Observational

Funder types: Other

Identifiers

NCT07168551

UNLF

Details and patient eligibility

About

1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients.
2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.

3 - To examine the relationship between serum uric acid levels and liver fibrosis severity*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD.

4- To identify potential mechanisms underlying the association*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.

Full description

Hyperuricemia is associated with nonalcoholic fatty liver disease (NAFLD), whereas whether the association differed by hyperuricemia onset age remained unclear. This study sought to investigate the associations of hyperuricemia onset age with the risk of incident NAFLD across adulthood.

Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.

Enrollment: 111 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age: Adults (typically 18-65 years old)

2 - Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg/m²

3- Hyperuricemia : Elevated serum uric acid levels (typically > 7 mg/dL for men and > 6 mg/dL for women)

Exclusion criteria

• excessive alcohol consumption ( > 20 gm /day in men and 10 in g /day in women )

  2- use of steatogenic within the past 6 months

  3- positive test for hepatitis B surface antigen and hepatitis B core antibody

  4- Drug induced liver injury and autoimmune hepatitis

  5 - cirrhosis and other causes of liver disease

Trial design

111 participants in 3 patient groups

1- obese +-nafld+- fibrosis

Description:

Obese patients with non alcoholic fatty liver disease with fibrosis

Treatment:

Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .

obese +- hyperuricemia +- nfld+- fibrosis

Description:

Obese patients with hyperuricemia and non alcoholic liver disease and fibrosis

Treatment:

Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .

Healthy controls

Description:

Healthy controls

Treatment:

Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .