Is wGRS Associated With DD Recurrence?

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Dupuytren Contracture

Study type: Observational

Funder types: Other

Identifiers

NCT02983162

201600670

Details and patient eligibility

About

Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease.

Objective: We aim to determine whether the wGRS is associated with recurrent DD.

Study design: An observational study, in which the participants of the GODDAF study are followed up.

Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease.

Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.

Enrollment: 427 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• DD patient
• participant in the GODDAF study
• genetic data passed the quality control
• surgical treatment of DD
• written informed consent

Exclusion criteria

• Decisionally incapacitated
• Patients treated for DD with collagenase or radiotherapy