Ischemia Reperfusion: Prostaglandins and Antioxidants

University of Essex

Status: Completed

Conditions: Ischemic Reperfusion Injury

Treatments: Drug: Prostaglandin inhibitor (Ibuprophen); Dietary Supplement: Antioxidant

Study type: Interventional

Funder types: Other

Identifiers

NCT01666587

IRAPC

DBD0300 (Other Identifier)

Details and patient eligibility

About

The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?

Enrollment: 12 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males
• Healthy females

Exclusion criteria

• Smokers
• Cardiovascular disease
• Peripheral vascular disease
• Neurological deficits
• Diabetes Type I or II
• Pregnant women
• Adverse reactions to Ibuprofen

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 4 patient groups

control

No Intervention group

Description:

Control trial to determine the impact of the ischemic injury on vascular function without intervention

Antioxidant load

Experimental group

Description:

Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery

Treatment:

Dietary Supplement: Antioxidant

Prostaglandin inhibition

Experimental group

Description:

Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery

Treatment:

Drug: Prostaglandin inhibitor (Ibuprophen)

Combined

Experimental group

Description:

Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery

Treatment:

Dietary Supplement: Antioxidant

Drug: Prostaglandin inhibitor (Ibuprophen)