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Ischemic Heart Disease Incidence and Indices of Body-fat Distribution

National Institutes of Health (NIH) logo

National Institutes of Health (NIH)

Status

Completed

Conditions

Myocardial Ischemia
Obesity
Cardiovascular Diseases
Heart Diseases
Coronary Disease

Study type

Observational

Funder types

NIH

Identifiers

NCT00005255
R01HL040844 (U.S. NIH Grant/Contract)
1137

Details and patient eligibility

About

To determine the association between ischemic heart disease incidence and anthropometric indices of body-fat distribution.

Full description

BACKGROUND:

Previous studies have demonstrated that abdominal obesity can be predictive of ischemic heart disease. These prospective cohort studies employed simple indices of body-fat distribution such as waist-to-hip circumference ratio or subscapular skinfold. Their similar results suggested that increased abdominal obesity conferred a two-fold increased risk of ischemic heart disease among middle-aged men. The two proposed studies permitted testing of alternative fat-distribution indices which might be stronger risk factors for ischemic heart disease incidence than the waist-to-hip-ratio or the subscapular skinfold.

DESIGN NARRATIVE:

Two parallel case-control studies were conducted. In both studies, subjects were measured for girth, skinfold, abdominal sagittal diameter, height, and weight. Analyses for both protocols considered men and women separately. Possible confounders of the association between fat-distribution indices and ischemic heart disease were considered and if required, adjusted for in multivariate analyses. Possible confounders included race, age, tobacco use, alcohol use, diabetes, social class, hypertension, cholesterol levels, and physical activity levels.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Sex

Male

Ages

Under 100 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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