Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT)

Capital Medical University

Status

Completed

Conditions

Acute Ischemic Stroke

Treatments

Procedure: Local ischemic post-conditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT05153655

PROTECT

Details and patient eligibility

About

Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The purpose of this proof-of-concept study is to determine the safety and tolerability of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.

Enrollment

18 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18-80 years;
Acute ischemic stroke caused by middle cerebral artery M1 segment occlusion;
Successful recanalization (mTICI 2b/3) after endovascular thrombectomy that confirmed by digital subtraction angiography;
Written informed consent provided by the patients or their legal relatives.

Exclusion criteria

Known diagnosis or clinical suspicion of cerebral vasculitis or fibromuscular dysplasia;
Difficulty in reaching the designated position of the balloon used for ischemic post-conditioning;
Stenting in the middle cerebral artery as rescue therapy during the thrombectomy procedures;
> 2 times of balloon dilations as rescue therapy due to angioplasty during the thrombectomy procedures;
Moderate or severe residual stenosis (≥ 50%) of the culprit artery after recanalization;
Difficulty in complying with ischemic post-conditioning or other conditions that the investigator considered inappropriate for inclusion.