Ischemic Preconditioning and Thiol-disulfide Balance

Konya Meram State Hospital

Status: Completed

Conditions: Tourniquets

Treatments: Other: Remote Ischemic Preconditioning; Other: sham group

Study type: Interventional

Funder types: Other

Identifiers

NCT05082207

ischemic preconditioning TDH

Details and patient eligibility

About

Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.

Enrollment: 60 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions

Exclusion criteria

• emergency operation,
• Underlying neurological disorder,
• Underlying peripheral vascular disease,
• other types of concurrent surgery.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Remote Ischaemic preconditioning (RIPC)

Experimental group

Description:

The group underwent Remote Ischemic Preconditioning.

Treatment:

Other: Remote Ischemic Preconditioning

Sham Group

Sham Comparator group

Description:

Sham control group without remote ischemic preconditioning

Treatment:

Other: sham group