Ischemic Preconditioning in Osteoarthritis and Back Pain

University of Illinois

Status: Enrolling

Conditions: Knee Osteoarthritis; Low Back Pain

Treatments: Device: Sham Intervention; Device: Ischemic Preconditioning

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT07003113

90SFE0071 (Other Grant/Funding Number)

2024-0021

Details and patient eligibility

About

We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

Enrollment: 24 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Reported Knee Pain using ACR Criteria
• Reported Back Pain using ODI Criteria > 12
• Ability to walk for at least 3 minutes without the use of aids
• Ability to provide written informed consent

Exclusion criteria

• Younger than 50 years old
• History of Knee or Hip Replacements
• History of steroid injection within the previous 6 months
• Presence of neuromuscular joint condition that affects lower extremity function
• History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
• History of heart failure or thrombosis
• Allergic to ultrasound gel
• History of spine surgery
• Non-English speaker
• Currently pregnant or intends to become pregnant during the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

IC Arm

Experimental group

Treatment:

Device: Ischemic Preconditioning

Sham Arm

Sham Comparator group

Treatment:

Device: Sham Intervention