Isoflurane at Subanesthetic Concentrations - 6

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 40% Nitrous oxide; Drug: 0.6% isoflurane; Drug: 0.4% isoflurane; Drug: 0.2% isoflurane; Other: Sham comparator

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000254

NIDA-08391-6

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-6

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Enrollment: 10 patients

Sex: Male

Ages: 21 to 34 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 4 patient groups

0% isoflurane

Sham Comparator group

Treatment:

Drug: 40% Nitrous oxide

Other: Sham comparator

0.2% isoflurane

Active Comparator group

Treatment:

Drug: 40% Nitrous oxide

Drug: 0.2% isoflurane

0.4% isoflurane

Active Comparator group

Treatment:

Drug: 40% Nitrous oxide

Drug: 0.4% isoflurane

0.6% isoflurane

Active Comparator group

Treatment:

Drug: 40% Nitrous oxide

Drug: 0.6% isoflurane