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Isoflurane at Subanesthetic Concentrations - 6

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The University of Chicago

Status and phase

Completed
Phase 2

Conditions

Opioid-Related Disorders
Substance-Related Disorders

Treatments

Other: Sham comparator
Drug: 40% Nitrous oxide
Drug: 0.6% isoflurane
Drug: 0.2% isoflurane
Drug: 0.4% isoflurane

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT00000254
NIDA-08391-6
R01DA008391 (U.S. NIH Grant/Contract)
R01-08391-6

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Enrollment

10 patients

Sex

Male

Ages

21 to 34 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

10 participants in 4 patient groups

0% isoflurane
Sham Comparator group
Treatment:
Drug: 40% Nitrous oxide
Other: Sham comparator
0.2% isoflurane
Active Comparator group
Treatment:
Drug: 0.2% isoflurane
Drug: 40% Nitrous oxide
0.4% isoflurane
Active Comparator group
Treatment:
Drug: 0.4% isoflurane
Drug: 40% Nitrous oxide
0.6% isoflurane
Active Comparator group
Treatment:
Drug: 0.6% isoflurane
Drug: 40% Nitrous oxide

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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