Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

University of Wuerzburg

Status: Completed

Conditions: Adrenal Insufficiency; Hashimoto Disease

Treatments: Drug: synacthen

Study type: Interventional

Funder types: Other

Identifiers

NCT00552487

112/05

Details and patient eligibility

About

The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.

Full description

Many patients with Hashimoto thyroiditis who are correctly substituted with thyroid hormones have an impaired well-being. in some people an isolated ACTH deficiency was found.

In this study a 1 µg ACTH test is performed to evaluate the adrenocortical function.

Enrollment: 62 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written informed consent

Exclusion criteria

• • hypothyroidism of other origin

  • pregnancy and lactation
  • oral contraception
  • glucocorticoid therapy during the last 2 months
  • History of malignancy or chronic infections (Hepatitis, HIV)

Trial design

62 participants in 4 patient groups

1

Other group

Description:

healthy people without Hashimoto disease receive a 1µg ACTH stimulation test

Treatment:

Drug: synacthen

2

Other group

Description:

patients with Hashimoto disease with well being receive a 1 µg ACTH stimulation test

Treatment:

Drug: synacthen

3

Other group

Description:

patients with Hashimoto disease an impaired well-being receive a 1 µg ACTH stimulation test

Treatment:

Drug: synacthen

4

Other group

Description:

patients with Hashimoto disease and negative TPO antibodies receive a 1µg ACTH stimulation test

Treatment:

Drug: synacthen