Isolated Anti-HBc Serological Profile in HIV Infected Patients: Immunological, Virological Characteristics and Response to Hepatitis B Vaccination (ANRSHBEP03)

ANRS, Emerging Infectious Diseases

Status: Completed

Conditions: HIV Infection; Hepatitis B

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT02323308

2010-A00511-38 (Other Identifier)

ANRS HB EP 03 CISOVAC

Details and patient eligibility

About

The aim of study is to describe the clinical, immunological, serological, virological and therapeutic characteristics of HIV+ patients harboring isolated anti-HBc profile and to assess the response to vaccination in these patients.

Enrollment: 55 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• HIV+ adults patients
• negative HBsAg
• negative a-HBs Ab
• positive HBc Ab
• without HBV - vaccination
• CD4 cell above 200 /mm3
• HIV viral load below 50 copies/mL

Exclusion criteria

• positive HBs antigenemia in the past
• transaminitis above fivefold upper normal limit
• PT<50% or Platelet <50 000/mm3
• ongoing opportunistic infection
• ongoing or recent systemic corticoid or immunomodulatory therapy, splenectomy, pregnancy, contra-indication to intramuscular injection, familial history of neurological disease.

Trial design

55 participants in 1 patient group

vaccination

Description:

Anti-HBV vaccine injection

Treatment:

Other: blood sampling