Isolating and Testing Circulating Tumor DNA and Soluble Immune Markers During the Course of Treatment for Lung Cancer

Mayo Clinic

Status: Completed

Conditions: Lung Neoplasms; Squamous Cell Carcinoma; Carcinoma, Non-small-cell Lung; Neoplasms, Pulmonary; Cancer of the Lung; Cancer of Lung; Neoplasms, Lung; Pulmonary Cancer; Pulmonary Neoplasms; Lung Cancer; Adenocarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT02410603

15-000373

Details and patient eligibility

About

The purpose of this study is to explore the detection of circulating tumor DNA, soluble immune markers, and the evaluation of peripheral blood mononuclear cells (PBMC).

Full description

Our plan is to collect blood from patients with advanced stage lung cancer who are scheduled to undergo systemic therapy. In this study we will utilize a novel technology for circulating tumor DNA detection in order to evaluate their presence in patients with lung cancer by comparing blood samples at six time points. We will obtain baseline blood and then collect blood at five time points during the course of the patient's chemotherapy treatments and at the end of treatment. These same blood collections will be used for the detection of soluble immune markers and evaluation of PBMCs.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Advanced (non-resectable) malignancy in the thorax
• Age >18 years old
• Willing and able to provide consent
• No prior history of neoadjuvant therapy

Exclusion criteria

• Age <18 years old
• Unable to provide consent
• Patients with hemoglobin less than 10 g/dL (to minimize the impact of potential iatrogenic anemia)