Isopropyl Alcohol Against Chlorhexidine - Isopropyl Alcohol as Antiseptics to Prevent Hemoculture's Contamination

Universidad de Guanajuato

Status and phase: Completed; Phase 3

Conditions: Infectious Diseases

Treatments: Biological: chlorhexidine in isopropyl alcohol; Biological: Isopropyl alcohol

Study type: Interventional

Funder types: Other

Identifiers

NCT01361997

2011HRAEB001

Details and patient eligibility

About

The purpose of this study is to determinate if 70% isopropyl alcohol is not inferior preventing contamination of peripheral hemocultures, compared with 2% chlorhexidine in 70% isopropyl alcohol.

Full description

The develop of contaminants in blood cultures is a problem of great impact to health institutions and patients, as they represent a waste of resources, and additionally increases the patient's hospital stay. The principal source of contaminant is the bacteria in the skin flora, so the greatest way to improve the sensibility of this test is to do an optimal skin antisepsis. It has been reported that 2% chlorhexidine gluconate in 70% isopropyl alcohol is superior that other skin disinfectants, and that 70% isopropyl alcohol has a high efficacy reducing the presence of bacteria on the skin, so both antiseptics are good options for skin antisepsis.

Enrollment: 1,102 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with suspected blood stream infection.
• Patients allocated in admission, hospitalization and intensive care units.

Exclusion criteria

• Patients with a single peripheral hemoculture.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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1,102 participants in 2 patient groups

Chlorhexidine in isopropyl alcohol

Experimental group

Description:

This arm is composed of 545 hospitalized patients with suspected blood stream infection, to test 2% chlorhexidine gluconate in 70% isopropyl alcohol.

Treatment:

Biological: chlorhexidine in isopropyl alcohol

Isopropyl alcohol

Experimental group

Description:

This arm is composed of 572 hospitalized patients with suspected blood stream infection, to test 70% isopropyl alcohol.

Treatment:

Biological: Isopropyl alcohol