Isovolumetric and Isocaloric Preloads of Various Types of Milk on Food Intake, Subjective Appetite and Glycemic Response

University of Toronto

Status and phase: Completed; Phase 2; Phase 1

Conditions: Obesity Prevention; Diabetes Prevention

Treatments: Other: Dietary intervention

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01025557

Milk Study - Experiment 1

DFO_24235

Details and patient eligibility

About

The purpose of this protocol is to study the effects of fluid milk products on satiety, food intake, and glucose metabolism in healthy young men and women. Experiment 1: The specific objective is to investigate isovolumetric amounts of milk (2% M.F.), chocolate milk (1% M.F.), a soy beverage, cow's milk-based infant formula, and water (control) on satiety and food intake and on blood glucose before and after a meal. A fixed volume approach is based on the commercially available serving size. Experiment 2 will examine equicaloric amounts of milk (2% M.F.), chocolate milk (1% M.F.), a soy beverage, cow's milk-based infant formula, a glucose drink and water (control) the treatments in order to investigate macronutrient composition on satiety and food intake and on blood glucose before and after the meal.

Enrollment: 52 patients

Sex: All

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Non-smoking
• Aged 20-30 years
• Body mass index between 20 and 24.9 kg/m2

Exclusion criteria

• Diabetes
• Medication
• Lactose-intolerance or allergies to milk
• Breakfast skippers and those on an energy restricted diet

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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52 participants in 5 patient groups

Chocolate milk

Experimental group

Treatment:

Other: Dietary intervention

Milk

Experimental group

Treatment:

Other: Dietary intervention

Infant formula

Experimental group

Treatment:

Other: Dietary intervention

Soy beverage

Experimental group

Treatment:

Other: Dietary intervention

Water

Experimental group

Treatment:

Other: Dietary intervention