IV and Intrathecal Ketamine in Cesarean Section

Assiut University

Status and phase: Completed; Phase 4

Conditions: Cesarean Section; Analgesia

Treatments: Drug: Intrathecal ketamine; Drug: Intravenous ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT05679375

Ketamine in Cesarean section

Details and patient eligibility

About

In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores and overall satisfaction in patients undergoing cesarean section.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

• Pregnant undergoing elective cesarean section

Exclusion Criteria

• Significant coexisting diseases (pregnancy-induced hypertension or diabetes)
• body mass index ≥40kg/m2, height <150cm
• Current use of pain medication including opioids
• history of substance abuse or hallucinations, cardiovascular disease, diabetes, multiple gestations
• chronic pain was excluded.
• contraindications to spinal anaesthesia,
• severely compromised fetus requiring general anesthesia and those patients who received labor analgesia

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Intrathecal Ketamine

Active Comparator group

Description:

Patients will receive intrathecal Ketamine 0.1mg/kg added to bupivacaine and morphine.

Treatment:

Drug: Intrathecal ketamine

Intravenous ketamine

Active Comparator group

Description:

Patients will receive IV Ketamine 0.25mg/kg after spinal anesthesia with bupivacaine and morphine.

Treatment:

Drug: Intravenous ketamine