IV Paracetamol Versus IV Dexketoprofen in Dysmenorrhea

Akdeniz University

Status and phase: Unknown; Phase 4

Conditions: Dysmenorrhea

Treatments: Drug: Dexketoprofen; Drug: Paracetamol

Study type: Interventional

Funder types: Other

Identifiers

NCT02373514

57051259-020/70177

Details and patient eligibility

About

Patients presented with dysmenorrhea composed the study population. One gram paracetamol and 50 mg dexketoprofen in 100 ml saline with a rapid infusion were compared in ceasing dysmenorrhea in emergency department.

Full description

Patients over 18 years old who presented with dysmenorrhea composed the study population. Patients received pain killer within the last six hours, physical findings consistent with peritoneal irritation, allergy to the study drugs, renal or liver failure, drug addiction, pregnancy or woman with lactation and denied to give inform consent were the exclusion criteria. The pain of the study patients are measured with visual analogue scale at baseline, 15th and 30th minutes. At the end of the 30 minutes, rescue drug need is also recorded.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with dysmenorrhea
• Patients over 18 years old

Exclusion criteria

• denied to give inform consent
• Renal or liver failure
• Allergy to the study drugs
• Receiving pain killer within the last 6 hours.
• Physical examination findings consistent with peritoneal irritation
• Pregnancy or patients with lactation
• Drug addiction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Paracetamol

Active Comparator group

Description:

Intravenous 1 gm paracetamol in 100 ml saline with rapid infusion

Treatment:

Drug: Paracetamol

Dexketoprofen

Active Comparator group

Description:

Intravenous 50 mg dexketoprofen in 100 ml saline with rapid infusion

Treatment:

Drug: Dexketoprofen