IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing

Rambam Health Care Campus

Status: Completed

Conditions: Infertility

Treatments: Procedure: embryo freezing; Procedure: oocyte vitrification

Study type: Interventional

Funder types: Other

Identifiers

NCT02026193

RMB-0439-13

Details and patient eligibility

About

The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle.

The purpose of this study is to compare the outcome of these two approaches.

Enrollment: 11 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IVF patients
• ovulation trigger with Decapeptyl 0.2 mg because of ovarian hyper-response: E2 on trigger day .12,000 pmol/l and/or >15 oocytes.
• Normal uterus

Exclusion criteria

• <20% fertilization rate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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11 participants in 2 patient groups

oocyte vitrification

Experimental group

Description:

All retrieved mature oocytes will be vitrified.

Treatment:

Procedure: oocyte vitrification

embryo freezing

Active Comparator group

Description:

All retrieved oocytes will be fertilized, and resulting embryos will be frozen.

Treatment:

Procedure: embryo freezing