IVF Offspring Born in Guangzhou (IVF-BIG)

Guangzhou Women and Children's Medical Center

Status: Enrolling

Conditions: Offspring, Adult; Host and Microbiome; Genetics; ART; Neurodevelopment

Study type: Observational

Funder types: Other

Identifiers

NCT03650829

2018080103

Details and patient eligibility

About

The IVF Offspring Born in Guangzhou Cohort Study (IVF-BIG) was established to investigate the short- and long-term effects of exposure in early life on the health of mothers and offspring in Guangzhou, China. Data are collected regarding assisted reproductive technology (ART), environmental, occupational and lifestyle exposures as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.

Full description

It has been 40 years since the first IVF baby born in the world. The effects of hormonal drugs used on women and health of IVF offspring have always been concerned in the reproductive field and in public. With the increase of the prevalence of infertility and development of ART, China is facing a IVF babies boom. It has been reported that ART was associated with higher risk of cancers among women undergoing treatment of ART, and an increased incidence of autism and noncommunicable chronic diseases, such as obesity, among IVF offspring. Epigenetics is documented as one of the possible mechanisms, while answers remain to be explored. A birth cohort would provide an opportunity to examine the short- and long-term effects of ART exposure on health consequences of the mothers and babies.

Enrollment: 3,000 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women with <20 weeks of gestation
• Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
• Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
• Pregnant women conceived by assited reproductive technology

Exclusion criteria

• None