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Sleep Characteristics in Infants With Joint Hypermobility

N

Nigde Omer Halisdemir University

Status

Enrolling

Conditions

Joint Hypermobility Syndrome
Infant
Sleep

Treatments

Behavioral: Brief Infant Sleep Questionnaire
Behavioral: Beighton Scoring system

Study type

Observational

Funder types

Other

Identifiers

NCT07121179
joint hypermobility

Details and patient eligibility

About

Joint hypermobility is defined as an increased range of motion in one or more joints compared to the normal range. The Beighton Scoring (BS) system is commonly used to distinguish individuals with generalized joint hypermobility from those without. Passive joint range of motion varies among infants, children, and adults. Since younger children exhibit greater joint mobility than older children and adults, age-specific revisions of the cut-off values are necessary for the diagnosis of Generalized Joint Hypermobility (GJH). To this end, a recent study suggested that children aged 12 to 60 months should be diagnosed with GJH if the BS is greater than 4.

Studies have shown that motor development in children with joint hypermobility is delayed during early childhood, although most children catch up with their peers before the age of two. Infants with joint hypermobility experience significant delays in both gross and fine motor development. Additionally, proprioceptive impairments have been identified in both children and adults with joint hypermobility. A study evaluating sensory processing skills in toddlers with GJH reported sensory processing difficulties compared to their non-GJH peers. A review of the literature reveals that GJH affects the musculoskeletal system, motor development, and sensory processing skills in infants; however, no studies have been found investigating sleep characteristics in infants with GJH. This study aims to investigate the sleep characteristics of term infants aged 6 to 9 months with GJH and to compare them with their non-GJH peers.

Full description

Ligamentous laxity and the resulting joint hypermobility are present in various conditions affecting children, such as Marfan syndrome and Ehlers-Danlos syndrome. However, in most cases, joint hypermobility is a limited condition referred to as Generalized Joint Hypermobility (GJH). GJH is defined as asymptomatic hypermobility in more than five joints. The Beighton Scoring (BS) system is commonly used to distinguish individuals with generalized joint hypermobility from those without. The BS system includes the following assessments: passive dorsiflexion of the fifth metacarpophalangeal joint, passive hyperextension of the elbow, passive hyperextension of the knee, passive apposition of the thumb to the flexor aspect of the forearm, and forward flexion of the trunk.

In children older than five years, a cut-off score of ≥6 is used to diagnose GJH. In adults up to 50 years of age, a score of ≥5 out of 9 indicates GJH, while a score of ≥4 out of 9 is considered positive for GJH in adults over 50 years.

Joint hypermobility can cause stability issues in the musculoskeletal system due to connective tissue laxity. This can trigger problems such as discomfort, restlessness, and difficulty finding a position, especially during sleep. Sleep disruptions due to nighttime restlessness or frequent position changes may also occur. Furthermore, most studies on joint hypermobility in the literature primarily involve adults. Early developmental assessments are crucial for preventing developmental delays that may emerge later in life.

Enrollment

54 estimated patients

Sex

All

Ages

6 to 9 months old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Term infants
  • Infants with joint hypermobility
  • Post-term infants between 6 and 9 months old

Exclusion criteria

  • Premature infants
  • Infants with congenital malformations
  • Infants diagnosed with metabolic, neurological, or genetic diseases
  • Infants with joint hypermobility due to any musculoskeletal disease
  • Children whose parents did not volunteer for the study

Trial design

54 participants in 2 patient groups

Joint hypermobility
Description:
Joint hypermobility is defined as an increased range of motion in one or more joints compared to the normal range. The Beighton Scoring system is commonly used to distinguish individuals with generalized joint hypermobility from those without. The Beighton Score system includes the following assessments: passive dorsiflexion of the fifth metacarpophalangeal joint, passive hyperextension of the elbow, passive hyperextension of the knee, passive apposition of the thumb to the flexor aspect of the forearm, and forward flexion of the trunk. Infants aged 6-9 months with a Beighton Score \> 4 will be included in the joint hypermobility group.
Treatment:
Behavioral: Beighton Scoring system
Behavioral: Brief Infant Sleep Questionnaire
Healthy infants
Description:
A control group consisting of healthy infants, born at term and 6-9-month-old infants without joint hypermobility
Treatment:
Behavioral: Beighton Scoring system
Behavioral: Brief Infant Sleep Questionnaire

Trial contacts and locations

1

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Central trial contact

Rabia ZORLULAR

Data sourced from clinicaltrials.gov

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