Joint Infection Following ACL Reconstruction

Peking University

Status: Completed

Conditions: Joint Infection

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04948281

M2017332

Details and patient eligibility

About

This study was conducted to analyze the effect of joint infection on the bone tunnel, graft and articular cartilage following arthroscopic single-bundle anterior cruciate ligament (ACL) reconstruction with autologous hamstring, to summarize the features of MR findings after joint infection, and to correlate these findings with their possible factors.

Full description

A retrospective matched cohort study was performed in 26 patients who underwent arthroscopic single-bundle ACL reconstruction with hamstring graft and developed postoperative joint infection in our institute from January 2002 to December 2017. They were matched 1:3 to patients who did not sustain joint infection after ACL reconstruction. MR scan was collected at the time of follow-up. Bone tunnel enlargement at tunnel aperture, midsection and exit of tibial and femoral tunnel was carefully assessed. Graft signal-to-noise quotient (SNQ) on MRI was calculated to evaluate graft maturity. Cartilage morphology was graded using Whole Organ Magnetic Resonance Imaging Score. A generalized linear mixed model was applied to analyze the effect of joint infection on the bone tunnel, graft and articular cartilage.

Enrollment: 104 patients

Sex: All

Ages: 16 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 16 to 50 years;
• Underwent single-bundle ACL reconstruction with autologous hamstring;
• Had valid follow-up magnetic resonance imaging (MRI) at least 1 year after surgery

Exclusion criteria

• Concomitant ligament injury which need surgical repair;
• Delayed onset of postoperative joint infection (>3 months after surgery).

Trial design

104 participants in 2 patient groups

Infection Group

Description:

A group of joint infection patients after arthroscopic ACL reconstruction surgery , diagnose was made according to American CDC criteria of joint infection

Treatment:

Other: no intervention

Control Group

Description:

A group of patients which were matched to infections group retrospectively one-to-three who did not sustain any kind of infection after ACL reconstruction.

Treatment:

Other: no intervention