Juvenile Autoimmune Necrotizing Myopathies (MYONECPED)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Immune-Mediated Necrotizing Myopathy

Study type: Observational

Funder types: Other

Identifiers

NCT04295785

2019PI192

Details and patient eligibility

About

Autoimmune necrotizing myopathies (AINM) in adult patients are characterized by severity of muscle damage, presence of necrosis with little inflammation on muscle biopsy and anti-HMGCR or anti-SRP auto-antibodies. Data on AINM in children are currently lacking. The purpose of this study is to specify the characteristics at AINM diagnosis, treatments and evolution of juvenile AINM with anti-HMGCR or anti-SRP antibodies.

Enrollment: 10 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• AINM histologically proved by predominant muscle fibers necrosis lesions associated with minimal or absent inflammatory lesions
• Either anti-SRP or anti-HMGCR antibodies positivity
• Disease onset before age 18

Exclusion criteria

• Seronegative necrotizing myopathies
• Forms compatible with another type of myositis (e.g. dermatomyositis)

Trial design

10 participants in 1 patient group

autoimmune necrotizing myopathy beginning before 18