K-RAS and EGFR in Lung Cancer (K-RAS_NSCLC)

Hellenic Cooperative Oncology Group

Status: Completed

Conditions: Non Small Cell Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT03951233

K-RAS_NSCLC

Details and patient eligibility

About

Retrospective analysis where patients with histologically confirmed Non-small cell lung cancer (NSCLC) were centrally evaluated for the presence of KRAS and EGFR mutations.

Full description

A retrospective analysis, performed by the Hellenic Co-operative Oncology Group (HeCOG), in samples from patients with histologically confirmed NSCLC, who had been treated within HeCOG-affiliated centres from March 2000 through December 2012, were centrally evaluated for the presence of KRAS and EGFR mutations. All patients had available clinicopathological data at diagnosis. Formalin-fixed, paraffin-embedded tissue blocks were retrospectively retrieved from the HeCOG tumor repository. Cytologic material was prospectively submitted for genotyping in more recent years (2010-2012).

Enrollment: 424 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with histologically confirmed NSCLC
• Signed and dated written informed consent
• Age 18 years
• Available cytological material

Exclusion Criteria: -

Trial design

424 participants in 2 patient groups

K-RAS and EGFR mutated

Wild type